APP intracellular domain is increased and soluble Aβ is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease

APP intracellular domain is increased and soluble Aβ is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease

Cholesterol is one of multiple factors, other than familial genetic mutations, that can influence amyloid-β peptide (Aβ) metabolism and accumulation in Alzheimer disease (AD). The effect of a high-cholesterol diet on amyloid precursor protein (APP) processing in brain has not been thoroughly studied...

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Bibliographic Details
Main Authors: Amee J George, R.M.Damian Holsinger, Catriona A McLean, Katrina M Laughton, Konrad Beyreuther, Genevieve Evin, Colin L Masters, Qiao-Xin Li
Format: Article
Language:English
Published: Elsevier 2004-06-01
Series:Neurobiology of Disease
Subjects:
Alzheimer disease
Transgenic mouse
Aβ amyloid
Amyloid precursor protein
AICD
Cholesterol
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610400021X

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http://www.sciencedirect.com/science/article/pii/S096999610400021X

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