Citrullination Licenses Calpain to Decondense Nuclei in Neutrophil Extracellular Trap Formation

Citrullination Licenses Calpain to Decondense Nuclei in Neutrophil Extracellular Trap Formation

Neutrophils respond to various stimuli by decondensing and releasing nuclear chromatin characterized by citrullinated histones as neutrophil extracellular traps (NETs). This achieves pathogen immobilization or initiation of thrombosis, yet the molecular mechanisms of NET formation remain elusive. Pe...

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Bibliographic Details
Main Authors: Stefanie Gößwein, Aylin Lindemann, Aparna Mahajan, Christian Maueröder, Eva Martini, Jay Patankar, Georg Schett, Christoph Becker, Stefan Wirtz, Nora Naumann-Bartsch, Marco E. Bianchi, Peter A. Greer, Günter Lochnit, Martin Herrmann, Markus F. Neurath, Moritz Leppkes
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
neutrophil
citrullination
PAD4
calpain
cell death
nucleus
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02481/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02481/full

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