Synthesis of Novel Sterically Demanding Carbo- and Heterocyclic β-Ketoesters

Synthesis of Novel Sterically Demanding Carbo- and Heterocyclic β-Ketoesters

We present an easy method for the synthesis of β-ketoesters starting from variouscarbocyclic and heterocyclic carboxylic acids and esters. The β-ketoester side-chain wasintroduced by a sequence involving α-deprotonation and quenching with CO2, conversion tothe corresponding acid chloride an...

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Bibliographic Details
Main Authors: Peter Stanetty, Thomas C. M. Fischer, Marko D. Mihovilovic
Format: Article
Language:English
Published: MDPI AG 2006-05-01
Series:Molecules
Subjects:
Chain elongation
β-ketoesters
ethyl acetate
heterocyclic esters
Online Access:http://www.mdpi.com/1420-3049/11/5/357/
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spelling doaj-96e5bc67eb59476b93542fe8782f8ff32020-11-25T00:15:28ZengMDPI AGMolecules1420-30492006-05-0111535736410.3390/11050357Synthesis of Novel Sterically Demanding Carbo- and Heterocyclic β-KetoestersPeter StanettyThomas C. M. FischerMarko D. MihovilovicWe present an easy method for the synthesis of β-ketoesters starting from variouscarbocyclic and heterocyclic carboxylic acids and esters. The β-ketoester side-chain wasintroduced by a sequence involving α-deprotonation and quenching with CO2, conversion tothe corresponding acid chloride and subsequent chain elongation using deprotonated ethylacetate.http://www.mdpi.com/1420-3049/11/5/357/Chain elongationβ-ketoestersethyl acetateheterocyclic esters
collection DOAJ
language English
format Article
sources DOAJ
author Peter Stanetty
Thomas C. M. Fischer
Marko D. Mihovilovic
spellingShingle Peter Stanetty
Thomas C. M. Fischer
Marko D. Mihovilovic
Synthesis of Novel Sterically Demanding Carbo- and Heterocyclic β-Ketoesters
Molecules
Chain elongation
β-ketoesters
ethyl acetate
heterocyclic esters
author_facet Peter Stanetty
Thomas C. M. Fischer
Marko D. Mihovilovic
author_sort Peter Stanetty
title Synthesis of Novel Sterically Demanding Carbo- and Heterocyclic β-Ketoesters
title_short Synthesis of Novel Sterically Demanding Carbo- and Heterocyclic β-Ketoesters
title_full Synthesis of Novel Sterically Demanding Carbo- and Heterocyclic β-Ketoesters
title_fullStr Synthesis of Novel Sterically Demanding Carbo- and Heterocyclic β-Ketoesters
title_full_unstemmed Synthesis of Novel Sterically Demanding Carbo- and Heterocyclic β-Ketoesters
title_sort synthesis of novel sterically demanding carbo- and heterocyclic ãžâ²-ketoesters
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2006-05-01
description We present an easy method for the synthesis of β-ketoesters starting from variouscarbocyclic and heterocyclic carboxylic acids and esters. The β-ketoester side-chain wasintroduced by a sequence involving α-deprotonation and quenching with CO2, conversion tothe corresponding acid chloride and subsequent chain elongation using deprotonated ethylacetate.
topic Chain elongation
β-ketoesters
ethyl acetate
heterocyclic esters
url http://www.mdpi.com/1420-3049/11/5/357/
work_keys_str_mv AT peterstanetty synthesisofnovelstericallydemandingcarboandheterocyclicaza2ketoesters
AT thomascmfischer synthesisofnovelstericallydemandingcarboandheterocyclicaza2ketoesters
AT markodmihovilovic synthesisofnovelstericallydemandingcarboandheterocyclicaza2ketoesters
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