Rapid surface accumulation of NMDA receptors increases glutamatergic excitation during status epilepticus

Rapid surface accumulation of NMDA receptors increases glutamatergic excitation during status epilepticus

After 1 h of lithium-pilocarpine status epilepticus (SE), immunocytochemical labeling of NMDA receptor NR1 subunits reveals relocation of subunits from the interior to the cell surface of dentate gyrus granule cells and CA3 pyramidal cells. Simultaneously, an increase in NMDA-miniature excitatory po...

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Bibliographic Details
Main Authors: David E. Naylor, Hantao Liu, Jerome Niquet, Claude G. Wasterlain
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Neurobiology of Disease
Subjects:
NMDA receptor trafficking
Status epilepticus
Epilepsy
Hippocampus
Synaptic excitation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113000065

Internet

http://www.sciencedirect.com/science/article/pii/S0969996113000065

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