Functional Expression in <em>Es</em><em>c</em><em>herichia coli</em> of the Disulfide-Rich Sea Anemone Peptide APETx2, a Potent Blocker of Acid-Sensing Ion Channel 3

Functional Expression in <em>Es</em><em>c</em><em>herichia coli</em> of the Disulfide-Rich Sea Anemone Peptide APETx2, a Potent Blocker of Acid-Sensing Ion Channel 3

Acid-sensing ion channels (ASICs) are proton-gated sodium channels present in the central and peripheral nervous system of chordates. ASIC3 is highly expressed in sensory neurons and plays an important role in inflammatory and ischemic pain. Thus, specific inhibitors of ASIC3 have the potential to b...

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Bibliographic Details
Main Authors: Glenn F. King, Mehdi Mobli, Raveendra Anangi, Lachlan D. Rash
Format: Article
Language:English
Published: MDPI AG 2012-07-01
Series:Marine Drugs
Subjects:
ASIC3
APETx2
heterologous expression
NMR
<em>E. coli</em>
Online Access:http://www.mdpi.com/1660-3397/10/7/1605

Internet

http://www.mdpi.com/1660-3397/10/7/1605

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