Association between GNAS1 T393C Polymorphism and Therapeutic Efficacy of Tyrosine Kinase Inhibitor in Pretreated Advanced Non-small Cell Lung Cancer with Unknown EGFR Mutation Status

Association between GNAS1 T393C Polymorphism and Therapeutic Efficacy of Tyrosine Kinase Inhibitor in Pretreated Advanced Non-small Cell Lung Cancer with Unknown EGFR Mutation Status

Background and objective Epidermal growth factor receptor (EGFR)-activating mutation predicts excellent response to EGFR tyrosine kinase inhibitors (TKIs). However, lung cancer patients are often with unknown EGFR mutation status because there are little tumor specimen to determine. TKIs induce tumo...

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Bibliographic Details
Main Authors: Wei HONG, Baochai LIN, Beibei ZHANG, Weimin MAO, Yiping ZHANG
Format: Article
Language:zho
Published: Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2014-04-01
Series:Chinese Journal of Lung Cancer
Subjects:
GNAS1 Gene
Polymorphism
Lung neoplasms
Tyrosine kinase inhibitor
Online Access:http://dx.doi.org/10.3779/j.issn.1009-3419.2014.04.06

Internet

http://dx.doi.org/10.3779/j.issn.1009-3419.2014.04.06

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