Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion

Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion

In animals, the protein kinase C (PKC) family has expanded into diversely regulated subgroups, including the Rho family-responsive PKN kinases. Here, we describe knockouts of all three mouse PKN isoforms and reveal that PKN2 loss results in lethality at embryonic day 10 (E10), with associated cardio...

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Bibliographic Details
Main Authors: Ivan Quétier, Jacqueline J.T. Marshall, Bradley Spencer-Dene, Sylvie Lachmann, Adele Casamassima, Claudio Franco, Sarah Escuin, Joseph T. Worrall, Priththivika Baskaran, Vinothini Rajeeve, Michael Howell, Andrew J. Copp, Gordon Stamp, Ian Rosewell, Pedro Cutillas, Holger Gerhardt, Peter J. Parker, Angus J.M. Cameron
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Cell Reports
Subjects:
PKC
protein kinase C
PKN
Protein kinase N
MEF
mouse embryonic fibroblasts
ES cells
Embryonic stem cells
4-OHT
4-hydroxytamoxifen
NCCs
neural crest cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715014904

Internet

http://www.sciencedirect.com/science/article/pii/S2211124715014904

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