Development and validation of a high-throughput calcium mobilization assay for the orphan receptor GPR88

Development and validation of a high-throughput calcium mobilization assay for the orphan receptor GPR88

Abstract Background GPR88 is an orphan G protein-coupled receptor highly expressed in the striatum and is implicated in basal ganglia-associated disorders. However, the receptor functions of GPR88 are still largely unknown due to the lack of potent and selective ligands appropriate for central nervo...

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Bibliographic Details
Main Authors: Ann M. Decker, Elaine A. Gay, Kelly M. Mathews, Taylor C. Rosa, Tiffany L. Langston, Rangan Maitra, Chunyang Jin
Format: Article
Language:English
Published: BMC 2017-03-01
Series:Journal of Biomedical Science
Subjects:
GPR88
Gαqi5
2-PCCA
High-throughput screen
Calcium mobilization
Online Access:http://link.springer.com/article/10.1186/s12929-017-0330-3

Internet

http://link.springer.com/article/10.1186/s12929-017-0330-3

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