Interconversion of functional motions between mesophilic and thermophilic adenylate kinases.
Dynamic properties are functionally important in many proteins, including the enzyme adenylate kinase (AK), for which the open/closed transition limits the rate of catalytic turnover. Here, we compare our previously published coarse-grained (double-well Gō) simulation of mesophilic AK from E. coli (...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-07-01
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Series: | PLoS Computational Biology |
Online Access: | http://europepmc.org/articles/PMC3136430?pdf=render |