Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia

Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia

Objective: Glycogen storage disease type 1a (GSD Ia) is a rare inherited metabolic disorder caused by mutations in the glucose-6-phosphatase (G6PC1) gene. When untreated, GSD Ia leads to severe fasting-induced hypoglycemia. Although current intensive dietary management aims to prevent hypoglycemia,...

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Bibliographic Details
Main Authors: Anouk M. La Rose, Venetia Bazioti, Joanne A. Hoogerland, Arthur F. Svendsen, Anouk G. Groenen, Martijn van Faassen, Martijn G.S. Rutten, Niels J. Kloosterhuis, Bertien Dethmers-Ausema, J. Hendrik Nijland, Gilles Mithieux, Fabienne Rajas, Folkert Kuipers, Michaël V. Lukens, Oliver Soehnlein, Maaike H. Oosterveer, Marit Westerterp
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Molecular Metabolism
Subjects:
Glycogen storage disease type 1a
Hypoglycemia
Corticosterone
Monocytes
Platelets
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821001101

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http://www.sciencedirect.com/science/article/pii/S2212877821001101

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