NH36 and F3 Antigen-Primed Dendritic Cells Show Preserved Migrating Capabilities and CCR7 Expression and F3 Is Effective in Immunotherapy of Visceral Leishmaniasis

NH36 and F3 Antigen-Primed Dendritic Cells Show Preserved Migrating Capabilities and CCR7 Expression and F3 Is Effective in Immunotherapy of Visceral Leishmaniasis

Physical contact between dendritic cells (DCs) and T cell lymphocytes is necessary to trigger the immune cell response. CCL19 and CCL21 chemokines bind to the CCR7 receptor of mature DCs, and of T cells and regulate DCs migration to the white pulp (wp) of the spleen, where they encounter lymphocytes...

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Bibliographic Details
Main Authors: Dirlei Nico, Fernanda Martins Almeida, Juliana Maria Motta, Fellipe Soares dos Santos Cardoso, Celio Geraldo Freire-de-Lima, Leonardo Freire-de-Lima, Paula Melo de Luca, Ana Maria Blanco Martinez, Alexandre Morrot, Clarisa Beatriz Palatnik-de-Sousa
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
visceral leishmaniasis
dendritic cells defective migration
CCR7 expression
nucleoside hydrolase
NH36
F3 domain
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00967/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00967/full

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