Nanoparticle conjugation of ginsenoside Rb3 inhibits myocardial fibrosis by regulating PPARα pathway

Nanoparticle conjugation of ginsenoside Rb3 inhibits myocardial fibrosis by regulating PPARα pathway

Background: Cardiac fibrosis occurs in ischemic and non-ischemic heart failure, hereditary cardiomyopathy, diabetes and aging. Energy metabolism, which serves a crucial function in the course and treatment of cardiovascular diseases, might have therapeutic benefits for myocardial fibrosis. Ginsenosi...

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Bibliographic Details
Main Authors: Yi Zhang, Haixia Ji, Ou Qiao, Zhi Li, Lorenzo Pecoraro, Xueqian Zhang, Xiaoying Han, Wenzhe Wang, Xinyu Zhang, Shuli Man, Juan Wang, Xia Li, Changxiao Liu, Luqi Huang, Wenyuan Gao
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Nanoparticles conjugation with ginsenoside Rb3 (NpRb3)
Myocardial fibrosis
Energy metabolism
Perixisome proliferation-activated receptor alpha (PPARα)
Transforming growth factor beta 1 (TGF-β1)
Oral bioavailability enhancement
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221004157

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