Filamin A Phosphorylation at Serine 2152 by the Serine/Threonine Kinase Ndr2 Controls TCR-Induced LFA-1 Activation in T Cells

Filamin A Phosphorylation at Serine 2152 by the Serine/Threonine Kinase Ndr2 Controls TCR-Induced LFA-1 Activation in T Cells

The integrin LFA-1 (CD11a/CD18) plays a critical role in the interaction of T cells with antigen presenting cells (APCs) to promote lymphocyte differentiation and proliferation. This integrin can be present either in a closed or in an open active conformation and its activation upon T-cell receptor...

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Bibliographic Details
Main Authors: Natalie Waldt, Anke Seifert, Yunus Emre Demiray, Eric Devroe, Benjamin E. Turk, Peter Reichardt, Charlie Mix, Annegret Reinhold, Christian Freund, Andreas J. Müller, Burkhart Schraven, Oliver Stork, Stefanie Kliche
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
LFA-1
TCR
Ndr2
Filamin A
Talin
Kindlin-3
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02852/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02852/full

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