Lupin Peptide T9 (GQEQSHQDEGVIVR) Modulates the Mutant PCSK9<sup>D374Y</sup> Pathway: in vitro Characterization of its Dual Hypocholesterolemic Behavior
GQEQSHQDEGVIVR (T9) is a peptide originated by the tryptic digestion of lupin β-conglutin that is absorbed in human intestinal Caco-2 cells. A previous study has shown that T9 impairs the protein−protein interaction between mutant D374Y Proprotein Convertase Subtilisin/Kexin 9 (PC...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-07-01
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| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/11/7/1665 |