An Expanded Role for HLA Genes: HLA-B Encodes a microRNA that Regulates IgA and Other Immune Response Transcripts

An Expanded Role for HLA Genes: HLA-B Encodes a microRNA that Regulates IgA and Other Immune Response Transcripts

We describe a novel functional role for the HLA-B locus mediated by its intron-encoded microRNA (miRNA), miR-6891-5p. We show that in vitro inhibition of miR-6891-5p impacts the expression of nearly 200 transcripts within the B-lymphoblastoid cell line (B-LCL) COX, affecting a large number of metabo...

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Bibliographic Details
Main Authors: Nilesh Chitnis, Peter M. Clark, Malek Kamoun, Catherine Stolle, F. Brad Johnson, Dimitri S. Monos
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
HLA-B
miR-6891-5p
mirtron
primary immunodeficiency
selective IgA deficiency
B lymphocyte
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00583/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00583/full

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