Adult Human Primary Cardiomyocyte-Based Model for the Simultaneous Prediction of Drug-Induced Inotropic and Pro-arrhythmia Risk

Adult Human Primary Cardiomyocyte-Based Model for the Simultaneous Prediction of Drug-Induced Inotropic and Pro-arrhythmia Risk

Cardiac safety remains the leading cause of drug development discontinuation. We developed a human cardiomyocyte-based model that has the potential to provide a predictive preclinical approach for simultaneously predicting drug-induced inotropic and pro-arrhythmia risk.Methods: Adult human primary c...

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Bibliographic Details
Main Authors: Nathalie Nguyen, William Nguyen, Brynna Nguyenton, Phachareeya Ratchada, Guy Page, Paul E. Miller, Andre Ghetti, Najah Abi-Gerges
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Physiology
Subjects:
human heart
adult human primary cardiomyocyte
pro-arrhythmia
inotropy
risk assessment
drug discovery and development
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.01073/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.01073/full

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