The molecular signature of the stroma response in prostate cancer-induced osteoblastic bone metastasis highlights expansion of hematopoietic and prostate epithelial stem cell niches.

The molecular signature of the stroma response in prostate cancer-induced osteoblastic bone metastasis highlights expansion of hematopoietic and prostate epithelial stem cell niches.

The reciprocal interaction between cancer cells and the tissue-specific stroma is critical for primary and metastatic tumor growth progression. Prostate cancer cells colonize preferentially bone (osteotropism), where they alter the physiological balance between osteoblast-mediated bone formation and...

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Bibliographic Details
Main Authors: Berna C Özdemir, Janine Hensel, Chiara Secondini, Antoinette Wetterwald, Ruth Schwaninger, Achim Fleischmann, Wolfgang Raffelsberger, Olivier Poch, Mauro Delorenzi, Ramzi Temanni, Ian G Mills, Gabri van der Pluijm, George N Thalmann, Marco G Cecchini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4259356?pdf=render

Internet

http://europepmc.org/articles/PMC4259356?pdf=render

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