3-(5-Nitrofuran-2-yl)prop-2-en-1-one Derivatives, with Potent Antituberculosis Activity, Inhibit A Novel Therapeutic Target, Arylamine <i>N</i>-acetyltransferase, in Mycobacteria

3-(5-Nitrofuran-2-yl)prop-2-en-1-one Derivatives, with Potent Antituberculosis Activity, Inhibit A Novel Therapeutic Target, Arylamine <i>N</i>-acetyltransferase, in Mycobacteria

In this study, the inhibitory potential of 3-(5-nitrofuran-2-yl)prop-2-en-1-one derivatives was evaluated against a panel of bacteria, as well as mammalian cell lines to determine their therapeutic index. In addition, we investigated the mechanism of antibiotic action of the derivatives to identify...

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Bibliographic Details
Main Authors: Neha Agre, Nilesh Tawari, Arundhati Maitra, Antima Gupta, Tulika Munshi, Mariam Degani, Sanjib Bhakta
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Antibiotics
Subjects:
tuberculosis
antibiotic resistance
5-nitrofuran
arylamine <i>N</i>-acetyltransferase
Online Access:https://www.mdpi.com/2079-6382/9/7/368

Internet

https://www.mdpi.com/2079-6382/9/7/368

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