The P2X7 Receptor: Central Hub of Brain Diseases

The P2X7 Receptor: Central Hub of Brain Diseases

The P2X7 receptor is a cation channel activated by high concentrations of adenosine triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming a wide pore that leads to cell death and increased release of ATP into the extracellular milieu. The P2X7 receptor is widely...

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Bibliographic Details
Main Authors: Roberta Andrejew, Ágatha Oliveira-Giacomelli, Deidiane Elisa Ribeiro, Talita Glaser, Vanessa Fernandes Arnaud-Sampaio, Claudiana Lameu, Henning Ulrich
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
P2X7 receptor
neurodegenerative diseases
psychiatric disorders
brain tumor
brain diseases
P2X7 receptor antagonists
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00124/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2020.00124/full

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