The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways.

The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways.

<h4>Background</h4>Human osteopontin (OPN), a known tumor associated protein, exists in different isoforms, whose function is unclear. It also possesses a RGD domain, which has been implicated in diverse function. Here, we use genetic approaches to systematically investigate the function...

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Bibliographic Details
Main Authors: Donald Courter, Hongbin Cao, Shirley Kwok, Christina Kong, Alice Banh, Peiwen Kuo, Donna M Bouley, Carmen Vice, Odd Terje Brustugun, Nicholas C Denko, Albert C Koong, Amato Giaccia, Quynh-Thu Le
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20224789/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20224789/?tool=EBI

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