The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways.
<h4>Background</h4>Human osteopontin (OPN), a known tumor associated protein, exists in different isoforms, whose function is unclear. It also possesses a RGD domain, which has been implicated in diverse function. Here, we use genetic approaches to systematically investigate the function...
Main Authors: | Donald Courter, Hongbin Cao, Shirley Kwok, Christina Kong, Alice Banh, Peiwen Kuo, Donna M Bouley, Carmen Vice, Odd Terje Brustugun, Nicholas C Denko, Albert C Koong, Amato Giaccia, Quynh-Thu Le |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-03-01
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Series: | PLoS ONE |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20224789/?tool=EBI |
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