Decitabine Enhances Vγ9Vδ2 T Cell-Mediated Cytotoxic Effects on Osteosarcoma Cells via the NKG2DL–NKG2D Axis

Decitabine Enhances Vγ9Vδ2 T Cell-Mediated Cytotoxic Effects on Osteosarcoma Cells via the NKG2DL–NKG2D Axis

γδ T cell-based immunotherapy for osteosarcoma (OS) has shown limited success thus far. DNA-demethylating agents not only induce tumor cell death but also have an immunomodulatory function. In this study, we have assessed the potential benefit of combining decitabine (DAC, a DNA demethylation drug)...

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Bibliographic Details
Main Authors: Zhan Wang, Zenan Wang, Shu Li, Binghao Li, Lingling Sun, Hengyuan Li, Peng Lin, Shengdong Wang, Wangsiyuan Teng, Xingzhi Zhou, Zhaoming Ye
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
decitabine
osteosarcoma
γδ T cell
MICB
UL16-binding protein 1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01239/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01239/full

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