BinomiRare: A robust test for association of a rare genetic variant with a binary outcome for mixed models and any case-control proportion

BinomiRare: A robust test for association of a rare genetic variant with a binary outcome for mixed models and any case-control proportion

Summary: Whole-genome sequencing (WGS) and whole-exome sequencing studies have become increasingly available and are being used to identify rare genetic variants associated with health and disease outcomes. Investigators routinely use mixed models to account for genetic relatedness or other clusteri...

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Bibliographic Details
Main Authors: Tamar Sofer, Jiwon Lee, Nuzulul Kurniansyah, Deepti Jain, Cecelia A. Laurie, Stephanie M. Gogarten, Matthew P. Conomos, Ben Heavner, Yao Hu, Charles Kooperberg, Jeffrey Haessler, Ramachandran S. Vasan, L. Adrienne Cupples, Brandon J. Coombes, Amanda Seyerle, Sina A. Gharib, Han Chen, Jeffrey R. O’Connell, Man Zhang, Daniel J. Gottlieb, Bruce M. Psaty, W.T. Longstreth, Jr., Jerome I. Rotter, Kent D. Taylor, Stephen S. Rich, Xiuqing Guo, Eric Boerwinkle, Alanna C. Morrison, James S. Pankow, Andrew D. Johnson, Nathan Pankratz, Alex P. Reiner, Susan Redline, Nicholas L. Smith, Kenneth M. Rice, Elizabeth D. Schifano
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:HGG Advances
Subjects:
genome sequencing
rare variant assocaition testing
diverse populations
targeted gene analysis
mixed models
Online Access:http://www.sciencedirect.com/science/article/pii/S266624772100021X

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http://www.sciencedirect.com/science/article/pii/S266624772100021X

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