Clemastine Fumarate Protects Against Myocardial Ischemia Reperfusion Injury by Activating the TLR4/PI3K/Akt Signaling Pathway

Clemastine Fumarate Protects Against Myocardial Ischemia Reperfusion Injury by Activating the TLR4/PI3K/Akt Signaling Pathway

Our pilot studies have shown that clemastine fumarate (CLE) can protect against myocardial ischemia-reperfusion injury (MIRI) through regulation of toll like receptor 4 (TLR4). However, the protective mechanism of CLE and related signaling pathways for MIRI remains unclear. The objective of this stu...

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Bibliographic Details
Main Authors: Xiaoxiao Yuan, Zhaodong Juan, Rui Zhang, Xiaotong Sun, Ru Yan, Feng Yue, Yaru Huang, Jiacheng Yu, Xiaohui Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
myocardial ischemia-reperfusion injury
inflammatory response
apoptosis
TLR4/PI3K/Akt
clemastine fumarate
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00028/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00028/full

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