Early-Life Maternal Deprivation Predicts Stronger Sickness Behaviour and Reduced Immune Responses to Acute Endotoxaemia in a Pig Model

Early-Life Maternal Deprivation Predicts Stronger Sickness Behaviour and Reduced Immune Responses to Acute Endotoxaemia in a Pig Model

Early-life adversity may have programming effects on neuroendocrine and immune adaptation mechanisms in humans and socially living animals. Using a pig model, we investigated the effect of daily 2-h maternal and littermate deprivation from postnatal days 2–15, either alone (DA) or in a group of litt...

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Bibliographic Details
Main Authors: Roberto Brückmann, Margret Tuchscherer, Armin Tuchscherer, Ulrike Gimsa, Ellen Kanitz
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
maternal deprivation
social isolation
early-life adversity
innate immunity
sickness behaviour
HPA axis
Online Access:https://www.mdpi.com/1422-0067/21/15/5212

Internet

https://www.mdpi.com/1422-0067/21/15/5212

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