Divergent Hemogen genes of teleosts and mammals share conserved roles in erythropoiesis: analysis using transgenic and mutant zebrafish

Divergent Hemogen genes of teleosts and mammals share conserved roles in erythropoiesis: analysis using transgenic and mutant zebrafish

Hemogen is a vertebrate transcription factor that performs important functions in erythropoiesis and testicular development and may contribute to neoplasia. Here we identify zebrafish Hemogen and show that it is considerably smaller (∼22 kDa) than its human ortholog (∼55 kDa), a striking difference...

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Bibliographic Details
Main Authors: Michael J. Peters, Sandra K. Parker, Jeffrey Grim, Corey A. H. Allard, Jonah Levin, H. William Detrich
Format: Article
Language:English
Published: The Company of Biologists 2018-08-01
Series:Biology Open
Subjects:
Anemia
CRISPR/Cas9
Gene editing
Hematopoiesis
Transcription
Online Access:http://bio.biologists.org/content/7/8/bio035576

Internet

http://bio.biologists.org/content/7/8/bio035576

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