Sirt6 Promotes DNA End Joining in iPSCs Derived from Old Mice

Sirt6 Promotes DNA End Joining in iPSCs Derived from Old Mice

Induced pluripotent stem cells (iPSCs) have great potential for treating age-related diseases, but the genome integrity of iPSCs is critically important. Here, we demonstrate that non-homologous end joining (NHEJ), rather than homologous recombination (HR), is less efficient in iPSCs from old mice t...

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Bibliographic Details
Main Authors: Wen Chen, Nana Liu, Hongxia Zhang, Haiping Zhang, Jing Qiao, Wenwen Jia, Songcheng Zhu, Zhiyong Mao, Jiuhong Kang
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
SirT6
Ku80
NHEJ repair
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717303029

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717303029

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