Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy

Damaged mitochondria can be selectively eliminated by mitophagy. Although two gene products mutated in Parkinson’s disease, PINK1, and Parkin have been found to play a central role in triggering mitophagy in mammals, how the pre-autophagosomal isolation membrane selectively and accurately engulfs da...

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Bibliographic Details
Main Authors: Koji Yamano, Adam I Fogel, Chunxin Wang, Alexander M van der Bliek, Richard J Youle
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-02-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/01612