Fibroblast paracrine TNF-α signaling elevates integrin A5 expression in idiopathic pulmonary fibrosis (IPF)

Fibroblast paracrine TNF-α signaling elevates integrin A5 expression in idiopathic pulmonary fibrosis (IPF)

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a poor prognosis. Inflammatory cytokines play a significant role in IPF pathology. However, the fibroblast itself is also believed to be the primary effector in IPF. We hypothesized that the fibroblasts themse...

Full description

Bibliographic Details
Main Authors: Gali Epstein Shochet, Elizabetha Brook, Lilach Israeli-Shani, Evgeny Edelstein, David Shitrit
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Respiratory Research
Subjects:
Idiopathic pulmonary fibrosis (IPF)
Fibroblasts
Integrin α5
TNF-α
Online Access:http://link.springer.com/article/10.1186/s12931-017-0606-x

Internet

http://link.springer.com/article/10.1186/s12931-017-0606-x

Similar Items