Mechanical stress changes the complex interplay between HO-1, inflammation and fibrosis, during excisional wound healing

Mechanical stress changes the complex interplay between HO-1, inflammation and fibrosis, during excisional wound healing

Mechanical stress following surgery or injury can promote pathological wound healing and fibrosis, and lead to functional loss and esthetic problems. Splinted excisional wounds can be used as model for inducing mechanical stress. The cytoprotective enzyme heme oxygenase-1 (HO-1) is thought to orches...

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Bibliographic Details
Main Authors: Niels A.J. Cremers, maarten esuttorp, marlous egerritsen, Ronald James Wong, Coby eVan Run-van Breda, gooitzen evan Dam, Katrien eBrouwer, Anne Marie eKuijpers-Jagtman, carine ecarels, Ditte eLundvig, Frank eWagener
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Medicine
Subjects:
Cleft Palate
Fibrosis
Heme Oxygenase-1
Inflammation
burn wounds
Mechanical Stress
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00086/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00086/full

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