eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction

eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction

Summary: Mitochondrial function declines during brain aging and is suspected to play a key role in age-induced cognitive decline and neurodegeneration. Supplementing levels of spermidine, a body-endogenous metabolite, has been shown to promote mitochondrial respiration and delay aspects of brain agi...

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Bibliographic Details
Main Authors: YongTian Liang, Chengji Piao, Christine B. Beuschel, David Toppe, Laxmikanth Kollipara, Boris Bogdanow, Marta Maglione, Janine Lützkendorf, Jason Chun Kit See, Sheng Huang, Tim O.F. Conrad, Ulrich Kintscher, Frank Madeo, Fan Liu, Albert Sickmann, Stephan J. Sigrist
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
eIF5A hypusination
spermidine
CG8005
deoxyhypusine synthase
eIF5A
brain aging
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002552

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721002552

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