LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease

LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease

Mutations in LRRK2 are thus far the most frequent known cause of autosomal dominant and idiopathic Parkinson's disease (PD) with prevalent mutations being found within the GTPase (R1441C/G) and kinase (G2019S) domains. Previous in vitro studies have revealed that R1441C and G2019S mutations are...

Full description

Bibliographic Details
Main Authors: Chen Yao, Rabih El Khoury, Wen Wang, Tara A. Byrd, Elizabeth A. Pehek, Colin Thacker, Xiongwei Zhu, Mark A. Smith, Amy L. Wilson-Delfosse, Shu G. Chen
Format: Article
Language:English
Published: Elsevier 2010-10-01
Series:Neurobiology of Disease
Subjects:
Leucine-rich repeat kinase 2
Parkinson's disease
Caenorhabditis elegans
Dopamine
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110000999

Internet

http://www.sciencedirect.com/science/article/pii/S0969996110000999

Similar Items