Single-cell RNA-seq dissects the intratumoral heterogeneity of triple-negative breast cancer based on gene regulatory networks

Single-cell RNA-seq dissects the intratumoral heterogeneity of triple-negative breast cancer based on gene regulatory networks

Triple-negative breast cancer (TNBC) is a subtype of breast cancer with high intratumoral heterogeneity. Recent studies revealed that TNBC patients might comprise cells with distinct molecular subtypes. In addition, gene regulatory networks (GRNs) constructed based on single-cell RNA sequencing (scR...

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Bibliographic Details
Main Authors: Shunheng Zhou, Yu-e Huang, Haizhou Liu, Xu Zhou, Mengqin Yuan, Fei Hou, Lihong Wang, Wei Jiang
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
triple-negative breast cancer
single-cell RNA sequencing
gene regulatory network
intratumoral heterogeneity
tumor microenvironment
cell-cell communication
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120303991

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http://www.sciencedirect.com/science/article/pii/S2162253120303991

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