A quantitative hematopoietic stem cell reconstitution protocol: Accounting for recipient variability, tissue distribution and cell half-lives

A quantitative hematopoietic stem cell reconstitution protocol: Accounting for recipient variability, tissue distribution and cell half-lives

Hematopoietic stem and progenitor cell (HSPC) transplantation is the paradigm for stem cell therapies. The protocol described here enables quantitative assessment of the body-wide HSPC reconstitution of different mature hematopoietic cells in mice based on their presence in circulating blood. The me...

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Bibliographic Details
Main Authors: Smrithi Rajendiran, Scott W. Boyer, E. Camilla Forsberg
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Stem Cell Research
Subjects:
Stem cells
Quantitative donor contribution
Tissue distribution
Mathematical modelling
Hematopoietic stem cells
Reconstitution
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506120304463

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http://www.sciencedirect.com/science/article/pii/S1873506120304463

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