Kinetic characteristics of propofol-induced inhibition of electron-transfer chain and fatty acid oxidation in human and rodent skeletal and cardiac muscles.

<h4>Introduction</h4>Propofol causes a profound inhibition of fatty acid oxidation and reduces spare electron transfer chain capacity in a range of human and rodent cells and tissues-a feature that might be related to the pathogenesis of Propofol Infusion Syndrome. We aimed to explore th...

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Main Authors: Tomáš Urban, Petr Waldauf, Adéla Krajčová, Kateřina Jiroutková, Milada Halačová, Valér Džupa, Libor Janoušek, Eva Pokorná, František Duška
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0217254