CRISPR/Cas9 ADCY7 Knockout Stimulates the Insulin Secretion Pathway Leading to Excessive Insulin Secretion

CRISPR/Cas9 ADCY7 Knockout Stimulates the Insulin Secretion Pathway Leading to Excessive Insulin Secretion

AimDespite the enormous efforts to understand Congenital hyperinsulinism (CHI), up to 50% of the patients are genetically unexplained. We aimed to functionally characterize a novel candidate gene in CHI.PatientA 4-month-old boy presented severe hyperinsulinemic hypoglycemia. A routine CHI genetic pa...

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Bibliographic Details
Main Authors: Yazeid Alhaidan, Henrik Thybo Christesen, Elena Lundberg, Mohammed A. Al Balwi, Klaus Brusgaard
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Endocrinology
Subjects:
genetics
metabolomics
congenital hyperinsulinism
hyperinsulinemic hypoglycemia
pediatrics
adenylyl cyclase
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.657873/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2021.657873/full

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