Glycogen synthase kinase-3β inhibitor SB216763 promotes DNA repair in ischemic retinal neurons

Glycogen synthase kinase-3β inhibitor SB216763 promotes DNA repair in ischemic retinal neurons

Glycogen synthase kinase-3β (GSK-3β) has been shown to attenuate DNA damage in nerve cells, thereby enhancing neuronal survival under pathological conditions; however, the underlying mechanism remains unclear. An in vitro serum-starvation retinal neuron model and in vivo ischemia/reperfusion retina...

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Bibliographic Details
Main Authors: Jing Zhang, Zhi-Peng Lai, Pei Chen, Yang Ying, Jing Zhuang, Ke-Ming Yu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Neural Regeneration Research
Subjects:
factor; gsk-3β; in vitro; injury; ligase iv; neuroprotection; optic nerve; pathways; protein; repair
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=2;spage=394;epage=400;aulast=Zhang

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=2;spage=394;epage=400;aulast=Zhang

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