Downregulation of Siah1 promotes colorectal cancer cell proliferation and migration by regulating AKT and YAP ubiquitylation and proteasome degradation

Downregulation of Siah1 promotes colorectal cancer cell proliferation and migration by regulating AKT and YAP ubiquitylation and proteasome degradation

Abstract Background Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Siah E3 ubiquitin protein ligase 1 (Siah1) has been identified as a tumor suppressor gene and plays an important role in the development of malignant tumors. However, the potential role and molecular...

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Bibliographic Details
Main Authors: Zhiyuan Xiao, Zhigang Wei, Danling Deng, Zhe Zheng, Yali Zhao, Shenglu Jiang, Dan Zhang, Ling-Jie Zhang, Mingmei Fan, Siqi Chen, ShuYang Wang, Yanqing Ding, Yaping Ye, Hongli Jiao
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Cancer Cell International
Subjects:
Colorectal cancer
Siah1
Ubiquitylation
Proliferation
Migration
Online Access:https://doi.org/10.1186/s12935-020-1124-3

Internet

https://doi.org/10.1186/s12935-020-1124-3

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