Design, Radiosynthesis and Preliminary Biological Evaluation in Mice of a Brain-Penetrant <sup>18</sup>F-Labelled σ<sub>2</sub> Receptor Ligand

Design, Radiosynthesis and Preliminary Biological Evaluation in Mice of a Brain-Penetrant <sup>18</sup>F-Labelled σ<sub>2</sub> Receptor Ligand

The σ<sub>2</sub> receptor (transmembrane protein 97), which is involved in cholesterol homeostasis, is of high relevance for neoplastic processes. The upregulated expression of σ<sub>2</sub> receptors in cancer cells and tissue in combination with the antiproliferative poten...

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Bibliographic Details
Main Authors: Rareş-Petru Moldovan, Daniel Gündel, Rodrigo Teodoro, Friedrich-Alexander Ludwig, Steffen Fischer, Magali Toussaint, Dirk Schepmann, Bernhard Wünsch, Peter Brust, Winnie Deuther-Conrad
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
σ<sub>2</sub> receptor
transmembrane protein 97
azaindoles
binding affinity
radiochemistry
fluorine-18 labeling
Online Access:https://www.mdpi.com/1422-0067/22/11/5447

Internet

https://www.mdpi.com/1422-0067/22/11/5447

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