Hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner

Hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner

Todd et al employ a PyMT-driven spontaneous murine mammary carcinoma model with mammary-specific deletion of hypoxia inducible factors Hif1α, Hif2α, or von Hippel-Lindau factor to further investigate their role in bone and lung metastasis. They find that HIF signaling in breast tumours controls tumo...

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Bibliographic Details
Main Authors: Vera M. Todd, Lawrence A. Vecchi, Miranda E. Clements, Katherine P. Snow, Cayla D. Ontko, Lauren Himmel, Christopher Pinelli, Marjan Rafat, Rachelle W. Johnson
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02648-3

Internet

https://doi.org/10.1038/s42003-021-02648-3

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