Rasa3 controls megakaryocyte Rap1 activation, integrin signaling and differentiation into proplatelet.

Rasa3 controls megakaryocyte Rap1 activation, integrin signaling and differentiation into proplatelet.

Rasa3 is a GTPase activating protein of the GAP1 family which targets Ras and Rap1. Ubiquitous Rasa3 catalytic inactivation in mouse results in early embryonic lethality. Here, we show that Rasa3 catalytic inactivation in mouse hematopoietic cells results in a lethal syndrome characterized by severe...

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Bibliographic Details
Main Authors: Patricia Molina-Ortiz, Séléna Polizzi, Eve Ramery, Stéphanie Gayral, Céline Delierneux, Cécile Oury, Shintaro Iwashita, Stéphane Schurmans
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-06-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4072513?pdf=render

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http://europepmc.org/articles/PMC4072513?pdf=render

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