A Method to Quantify Cell-Free Fetal DNA Fraction in Maternal Plasma Using Next Generation Sequencing: Its Application in Non-Invasive Prenatal Chromosomal Aneuploidy Detection.

A Method to Quantify Cell-Free Fetal DNA Fraction in Maternal Plasma Using Next Generation Sequencing: Its Application in Non-Invasive Prenatal Chromosomal Aneuploidy Detection.

OBJECTIVE:The fraction of circulating cell-free fetal (cff) DNA in maternal plasma is a critical parameter for aneuploidy screening with non-invasive prenatal testing, especially for those samples located in equivocal zones. We developed an approach to quantify cff DNA fractions directly with sequen...

Full description

Bibliographic Details
Main Authors: Xu-Ping Xu, Hai-Yan Gan, Fen-Xia Li, Qi Tian, Jun Zhang, Rong-Liang Liang, Ming Li, Xue-Xi Yang, Ying-Song Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4713075?pdf=render

Internet

http://europepmc.org/articles/PMC4713075?pdf=render

Similar Items