Melatonin protects against environmental stress-induced fetal growth restriction via suppressing ROS-mediated GCN2/ATF4/BNIP3-dependent mitophagy in placental trophoblasts

Melatonin protects against environmental stress-induced fetal growth restriction via suppressing ROS-mediated GCN2/ATF4/BNIP3-dependent mitophagy in placental trophoblasts

Gestational exposure to environmental stress induces fetal growth restriction (FGR), and thereby increasing the risk of infant death and chronic noncommunicable diseases in adults. However, the mechanism by which environmental stress induces FGR remains unclear. Based on case-control study, we found...

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Bibliographic Details
Main Authors: Hua-Long Zhu, Xue-Ting Shi, Xiao-Feng Xu, Guo-Xiang Zhou, Yong-Wei Xiong, Song-Jia Yi, Wei-Bo Liu, Li-Min Dai, Xue-Lin Cao, De-Xiang Xu, Hua Wang
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Redox Biology
Subjects:
Melatonin
Mitophagy
Environmental stress
ROS
Fetal growth restriction
Placenta
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721000021

Internet

http://www.sciencedirect.com/science/article/pii/S2213231721000021

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