Discovery of Novel Small Molecules that Block Myofibroblast Formation: Implications for Capsular Contracture Treatment

Background:. Capsular contracture is a devastating complication that occurs in patients undergoing implant-based breast reconstruction. Ionizing radiation drives and exacerbates capsular contracture in part by activating cytokines, including transforming growth factor-beta (TGF-β). TGF-β promotes my...

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Bibliographic Details
Main Authors: Rachel H. Park, BA, Stephen J. Pollock, BSc, Richard P. Phipps, PhD, Howard N. Langstein, MD, Collynn F. Woeller, PhD
Format: Article
Language:English
Published: Wolters Kluwer 2019-09-01
Series:Plastic and Reconstructive Surgery, Global Open
Online Access:http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000002430