Efficacy of Combined in-vivo Electroporation-Mediated Gene Transfer of VEGF, HGF, and IL-10 on Skin Flap Survival, Monitored by Label-Free Optical Imaging: A Feasibility Study

Efficacy of Combined in-vivo Electroporation-Mediated Gene Transfer of VEGF, HGF, and IL-10 on Skin Flap Survival, Monitored by Label-Free Optical Imaging: A Feasibility Study

Preventing surgical flaps necrosis remains challenging. Laser Doppler imaging and ultrasound can monitor blood flow in flap regions, but they do not directly measure the cellular response to ischemia. The study aimed to investigate the efficacy of synergistic in-vivo electroporation-mediated gene tr...

Full description

Bibliographic Details
Main Authors: S. Morteza Seyed Jafari, Fabian Blank, Hallie E. Ramser, Alan E. Woessner, Maziar Shafighi, Thomas Geiser, Kyle P. Quinn, Robert E. Hunger, Amiq Gazdhar
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Surgery
Subjects:
cell metabolism
flap survival
gene delivery
HGF
IL-10
in-vivo electroporation
Online Access:https://www.frontiersin.org/articles/10.3389/fsurg.2021.639661/full

Internet

https://www.frontiersin.org/articles/10.3389/fsurg.2021.639661/full

Similar Items