Novel ecto-tagged integrins reveal their trafficking in live cells
Integrins are cell-surface adhesion receptors that are modulated by endo-exocytic trafficking, but existing tools to study this process can interfere with function. Here the authors develop β1 integrins carrying traceable tags in the extracellular domain; a pH-sensitive pHlourin tag or a HaloTag to...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2017-09-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00646-w |