Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics simulation study

Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics simulation study

Omolbanin Shahraki,1,2 Najmeh Edraki,1 Mehdi Khoshneviszadeh,1,2 Farshid Zargari,1 Sara Ranjbar,1,2 Luciano Saso,3 Omidreza Firuzi,1 Ramin Miri1 1Medicinal and Natural Products Chemistry Research Center, 2Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences,...

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Bibliographic Details
Main Authors: Shahraki O, Edraki N, Khoshneviszadeh M, Zargari F, Ranjbar S, Saso L, Firuzi O, Miri R
Format: Article
Language:English
Published: Dove Medical Press 2017-02-01
Series:Drug Design, Development and Therapy
Subjects:
Cancer
P-glycoprotein
Multidrug resistance
1
4-Dihydropyridine
Molecular dynamics simulation
Online Access:https://www.dovepress.com/novel-5-oxo-hexahydroquinoline-derivatives-design-synthesis-in-vitro-p-peer-reviewed-article-DDDT

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https://www.dovepress.com/novel-5-oxo-hexahydroquinoline-derivatives-design-synthesis-in-vitro-p-peer-reviewed-article-DDDT

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