Single-Molecule Dynamics and Discrimination between Hydrophilic and Hydrophobic Amino Acids in Peptides, through Controllable, Stepwise Translocation across Nanopores

Single-Molecule Dynamics and Discrimination between Hydrophilic and Hydrophobic Amino Acids in Peptides, through Controllable, Stepwise Translocation across Nanopores

In this work, we demonstrate the proof-of-concept of real-time discrimination between patches of hydrophilic and hydrophobic monomers in the primary structure of custom-engineered, macro-dipole-like peptides, at uni-molecular level. We employed single-molecule recordings to examine the ionic current...

Full description

Bibliographic Details
Main Authors: Alina Asandei, Isabela S. Dragomir, Giovanni Di Muccio, Mauro Chinappi, Yoonkyung Park, Tudor Luchian
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Polymers
Subjects:
nanopore
peptide sensing
electrophysiology
single-molecule sequencing
Online Access:http://www.mdpi.com/2073-4360/10/8/885

Internet

http://www.mdpi.com/2073-4360/10/8/885

Similar Items