Protocatechuic Acid Extends Survival, Improves Motor Function, Diminishes Gliosis, and Sustains Neuromuscular Junctions in the hSOD1<sup>G93A</sup> Mouse Model of Amyotrophic Lateral Sclerosis

Protocatechuic Acid Extends Survival, Improves Motor Function, Diminishes Gliosis, and Sustains Neuromuscular Junctions in the hSOD1<sup>G93A</sup> Mouse Model of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a devastating disorder characterized by motor neuron apoptosis and subsequent skeletal muscle atrophy caused by oxidative and nitrosative stress, mitochondrial dysfunction, and neuroinflammation. Anthocyanins are polyphenolic compounds found in berries that pos...

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Bibliographic Details
Main Authors: Lilia A. Koza, Aimee N. Winter, Jessica Holsopple, Angela N. Baybayon-Grandgeorge, Claudia Pena, Jeffrey R. Olson, Randall C. Mazzarino, David Patterson, Daniel A. Linseman
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Nutrients
Subjects:
amyotrophic lateral sclerosis
anti-inflammatory
antioxidant
phenolic acid
neuroprotective
neurodegeneration
Online Access:https://www.mdpi.com/2072-6643/12/6/1824

Internet

https://www.mdpi.com/2072-6643/12/6/1824

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