Intranasal Niosomal <i>In Situ</i> Gel as a Promising Approach for Enhancing Flibanserin Bioavailability and Brain Delivery: In Vitro Optimization and <i>Ex Vivo</i>/<i>In Vivo</i> Evaluation

Intranasal Niosomal <i>In Situ</i> Gel as a Promising Approach for Enhancing Flibanserin Bioavailability and Brain Delivery: In Vitro Optimization and <i>Ex Vivo</i>/<i>In Vivo</i> Evaluation

Flibanserin (FLB) is a multifunctional serotonergic agent that was recently approved by the FDA for the oral treatment of premenopausal women with hypoactive sexual desire disorder. FLB is a centrally acting drug that has a low oral bioavailability of 33% owing to its exposure to the hepatic first-p...

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Bibliographic Details
Main Authors: Usama A. Fahmy, Shaimaa M. Badr-Eldin, Osama A. A. Ahmed, Hibah M. Aldawsari, Singkome Tima, Hani Z. Asfour, Mohammed W. Al-Rabia, Aya A. Negm, Muhammad H. Sultan, Osama A. A. Madkhali, Nabil A. Alhakamy
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Pharmaceutics
Subjects:
flibanserin
niosomes
Span<sup>®</sup> 85
cholesterol
gellan gum
ex vivo permeation
Online Access:https://www.mdpi.com/1999-4923/12/6/485

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https://www.mdpi.com/1999-4923/12/6/485

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